RNA of a putative non-A to E hepatitis virus, designated GB virus C (GBV-C), was detected in 40 (6.2%) of 645 hemodialysis patients, at a frequency significantly higher than in 3 (0.9%) of 336 blood donors in Japan (p<0.001).
A history of transfusion was more frequent (88 vs. 58%, p<0.001), the duration of dialysis was longer (13.2 ± 7.9 vs. 7.9 ± 6.5 years, p<0.001), and the detection of hepatitis C virus RNA was more often (38 vs. 18%, p<0.01) in the 40 patients with GBV-C RNA than in the 605 patients without it.
The prevalence of GBV-C RNA varied widely from 0 to 10% among the 8 dialysis centers.
These results indicate that hemodialysis patients would be at increased risk of GBV-C transmitted by transfusions.
The detection of GBV-C RNA in the 5 patients without a history of transfusion and a high prevalence restricted to certain dialysis centers would reflect nosocomial infection.
Mots-clés Pascal : Insuffisance rénale, Chronique, Hémodialyse, Séropositivité, Virus hépatite C, Flaviviridae, Virus, Virus hépatite ni A ni B, Traitement, Complication, Epidémiologie, Homme, Mongoloïde, Japon, Asie, Appareil urinaire pathologie, Rein pathologie, Epuration extrarénale, Immunopathologie, Virose, Infection
Mots-clés Pascal anglais : Renal failure, Chronic, Hemodialysis, Seropositivity, Hepatitis C virus, Flaviviridae, Virus, Non A non B hepatitis virus, Treatment, Complication, Epidemiology, Human, Mongoloid, Japan, Asia, Urinary system disease, Kidney disease, Extrarenal dialysis, Immunopathology, Viral disease, Infection
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0350237
Code Inist : 002B27B03. Création : 12/09/1997.