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GB virus C and hepatitis C virus infections in hemodialysis patients in eight Japanese centers.
NEPHRON, vol. 76, n° 2, 1997, pages 171-175, 18 réf., ISSN 0028-2766, CHE
WATANABE (T.), ISHIGURO (M.), KAMETANI (M.), SUGAI (Y.), TAKAKUWA (K.), AKAHANE (Y.), MASUKO (K.), SHIMIZU (M.), KOJIMA (M.), FUJITA (K.), TSUDA (F.), OKAMOTO (H.)
RNA of a putative non-A to E hepatitis virus, designated GB virus C (GBV-C), was detected in 40 (6.2%) of 645 hemodialysis patients, at a frequency significantly higher than in 3 (0.9%) of 336 blood donors in Japan (p<0.001).
A history of transfusion was more frequent (88 vs. 58%, p<0.001), the duration of dialysis was longer (13.2 ± 7.9 vs. 7.9 ± 6.5 years, p<0.001), and the detection of hepatitis C virus RNA was more often (38 vs. 18%, p<0.01) in the 40 patients with GBV-C RNA than in the 605 patients without it.
The prevalence of GBV-C RNA varied widely from 0 to 10% among the 8 dialysis centers.
These results indicate that hemodialysis patients would be at increased risk of GBV-C transmitted by transfusions.
The detection of GBV-C RNA in the 5 patients without a history of transfusion and a high prevalence restricted to certain dialysis centers would reflect nosocomial infection.
Mots-clés BDSP : Insuffisance rénale, Urémie chronique, Hémodialyse, Séropositivité, Virus, Thérapeutique, Complication, Epidémiologie, Homme, Japon, Asie, Appareil urinaire [pathologie], Rein [pathologie], Appareil épuration extrarénale, Virose, Infection
Mots-clés Pascal : Insuffisance rénale, Chronique, Hémodialyse, Séropositivité, Virus hépatite C, Flaviviridae, Virus, Virus hépatite ni A ni B, Traitement, Complication, Epidémiologie, Homme, Mongoloïde, Japon, Asie, Appareil urinaire pathologie, Rein pathologie, Epuration extrarénale, Immunopathologie, Virose, Infection
Mots-clés Pascal anglais : Renal failure, Chronic, Hemodialysis, Seropositivity, Hepatitis C virus, Flaviviridae, Virus, Non A non B hepatitis virus, Treatment, Complication, Epidemiology, Human, Mongoloid, Japan, Asia, Urinary system disease, Kidney disease, Extrarenal dialysis, Immunopathology, Viral disease, Infection
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