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  1. Maternal smoking and urinary organ malformations.

    Article - En anglais

    Background

    In order to investigate whether an earlier reported association between maternal smoking during pregnancy and urinary organ malformations could be confirmed, a study was made using Swedish health registries.

    Methods

    Infants with kidney malformations (n=483) and infants with other urinary organ malformations with no primary involvement of the kidney (s) (n=719) were selected among 1 117 021 infants born 1983-1993 with known smoking exposure in early pregnancy.

    Results

    A moderate, statistically significant association between maternal smoking and kidney malformations was found (adjusted odds ratio [OR]=1.22,95% confidence interval [CI] : 1.00-1.48).

    With the exception of genetic renal polycystic disease, the main subgroups of kidney malformations showed similar OR.

    For other urinary organ malformations, no association with smoking could be detected (OR=0.93,95% Cl : 0.79-1.11).

    Conclusions

    This study supports an association between maternal smoking during pregnancy and kidney malformations.

    No obvious confounders were detected but further work is needed before a causal inference can be made.

    Mots-clés Pascal : Tabagisme, Mère, Malformation, Appareil urinaire, Rein, Tabagisme passif, Epidémiologie, Facteur risque, Nouveau né, Homme, Suède, Europe, Gestation pathologie, Maladie congénitale, Rein pathologie, Appareil urinaire pathologie, Foetus pathologie

    Mots-clés Pascal anglais : Tobacco smoking, Mother, Malformation, Urinary system, Kidney, Passive smoking, Epidemiology, Risk factor, Newborn, Human, Sweden, Europe, Pregnancy disorders, Congenital disease, Kidney disease, Urinary system disease, Fetal diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0350227

    Code Inist : 002B20F02. Création : 12/09/1997.