In order to investigate whether an earlier reported association between maternal smoking during pregnancy and urinary organ malformations could be confirmed, a study was made using Swedish health registries.
Infants with kidney malformations (n=483) and infants with other urinary organ malformations with no primary involvement of the kidney (s) (n=719) were selected among 1 117 021 infants born 1983-1993 with known smoking exposure in early pregnancy.
A moderate, statistically significant association between maternal smoking and kidney malformations was found (adjusted odds ratio [OR]=1.22,95% confidence interval [CI] : 1.00-1.48).
With the exception of genetic renal polycystic disease, the main subgroups of kidney malformations showed similar OR.
For other urinary organ malformations, no association with smoking could be detected (OR=0.93,95% Cl : 0.79-1.11).
This study supports an association between maternal smoking during pregnancy and kidney malformations.
No obvious confounders were detected but further work is needed before a causal inference can be made.
Mots-clés Pascal : Tabagisme, Mère, Malformation, Appareil urinaire, Rein, Tabagisme passif, Epidémiologie, Facteur risque, Nouveau né, Homme, Suède, Europe, Gestation pathologie, Maladie congénitale, Rein pathologie, Appareil urinaire pathologie, Foetus pathologie
Mots-clés Pascal anglais : Tobacco smoking, Mother, Malformation, Urinary system, Kidney, Passive smoking, Epidemiology, Risk factor, Newborn, Human, Sweden, Europe, Pregnancy disorders, Congenital disease, Kidney disease, Urinary system disease, Fetal diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0350227
Code Inist : 002B20F02. Création : 12/09/1997.