Data from the study of the British 1958 birth cohort, National Child Development Study (NCDS), has allowed wider investigation of the relationship between retarded fetal growth and risk of adult hypertension.
A history of self-reported hypertension was related to fetal growth in 3308 parous cohort members.
Fetal growth, the measure used, is the difference in actual birthweight from that expected for the gestational age and subsequent adult height.
The relationships were investigated both linearly and non-linearly adjusting for potential confounders.
After adjustment for confounding factors, including adult weight for height, retarded fetal growth was associated with reported hypertension particularly when not confined to pregnancy.
The latter was also associated with accelerated fetal growth, moderate or severe hypertension in the mother when pregnant with the cohort member, being relatively taller than your mother, and lack of educational qualifications.
Hypertension confined to pregnancy was more likely among women who were themselves firstborn or older at childbirth.
Neither maternal smoking during cohort's gestation nor cohort member's gestational age had a significant effect.
The results are consistent with previous reports that fetal growth effects are less marked if gestation is short.
Mots-clés Pascal : Hypertension artérielle, Mère, Développement foetal, Retard staturopondéral, Poids naissance, Epidémiologie, Facteur risque, Foetus, Royaume Uni, Europe, Appareil circulatoire pathologie, Gestation pathologie, Mère pathologie, Foetus pathologie
Mots-clés Pascal anglais : Hypertension, Mother, Fetal development, Growth retardation, Birth weight, Epidemiology, Risk factor, Fetus, United Kingdom, Europe, Cardiovascular disease, Pregnancy disorders, Maternal diseases, Fetal diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0349798
Code Inist : 002B20F02. Création : 12/09/1997.