The aims of this study were the following : 1) to estimate the prevalence of hepatitis C virus (HCV) antibody (anti-HCV) in a population-based survey of French residents not selected for risk factors ; 2) to investigate the association between anti-HCV seropositivity, viremia, the infecting HCV genotype, and the alanine transaminase (ALT) level ; and 3) to identify risk factors for HCV infection by a nested case control study within this survey sample.
The anti-HCV seroprevalence survey was performed in 6,283 volunteers (20-to 59-years-old) randomly selected from 45,377 consecutive individuals undergoing routine medical checkup in social security medical centers covering 4 of the 22 « regions » of France.
Seventy-two volunteers were anti-HCV positive, a crude prevalence of 1.15%. Fifty percent of these positive volunteers also had an abnormal ALT level and 81% were HCV-RNA positive by polymerase chain reaction (PCR).
The prevalence weighted for age, sex, and place of residence was 1.05% (95% CI : 0.75-1.34).
The weighted prevalence was lower among men>40-years-old (0.5% ; 95% CI : 0.1-1.0) and was close to 1% in all other age and sex groups.
Prevalence was inversely correlated with socio-professional status with the highest rate being found among those with no paid employment (2.2% ; 95% CI : 1.3-3.0).
The HCV prevalence (1.7% ; 95% CI : 1.0-2.3) was highest in southeastern France. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Incidence, Prévalence, Séropositivité, Virémie, Génotype, Virus hépatite C, Flaviviridae, Virus, Facteur risque, Etude statistique, Homme, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Incidence, Prevalence, Seropositivity, Viremia, Genotype, Hepatitis C virus, Flaviviridae, Virus, Risk factor, Statistical study, Human, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0342674
Code Inist : 002B30A01A2. Création : 12/09/1997.