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  1. Identification of women with T1-T2 breast cancer at low risk of positive axillary nodes.

    Article, Communication - En anglais

    Annual Meeting of the Society of Surgical Oncology. Atlanta, Georgia (USA), 1996/03/21.

    Background and Objectives 

    The diagnostic and therapeutic significance of axillary dissection has been questioned.

    We sought to define a subgroup of patients with early-stage breast cancer who are at low risk for positive axillary nodes.

    Methods 

    Between 1970 and 1995,1,598 women with stage I and II breast cancer underwent level I-II axillary dissection with a minimum of 10 nodes removed.

    The following factors were examined in univariate analysis for predicting positive nodes :

    • race, method of detection, location of the primary tumor, age, menopausal status, obesity,

    • ER status,

    • PR status, pathologic tumor size, lymphatic vascular invasion, tumor grade, and histology.

    Results 

    Four hundred and forty-five of the 1,598 patients (27.8%) had histologically positive axillary nodes.

    Significant factors in univariate analysis for positive nodes included : tumor size, lymphatic vascular invasion, grade, method of detection, primary tumor location, and age.

    The only group of women with a 0% risk of axillary nodes were those in whom the pathologic tumor size was ¾5 mm and mammographically detected.

    A 5-10% risk of positive axillary nodes was identified in women with (1) pathologic tumor size 6-10 mm, mammographically detected, and age 540 years, and (2) tubular carcinoma ¾10 mm.

    Tumors detected on physical examination with or without mammography and women ¾40 years had a significantly increased risk of nodes.

    In multivariate analysis lymphatic vascular invasion (P<0. (...)

    Mots-clés Pascal : Carcinome, Glande mammaire, Stade précoce, Evaluation, Facteur risque, Extension, Ganglion lymphatique, Pronostic, Résultat, Homme, Femelle, Tumeur maligne, Glande mammaire pathologie, Lymphatique pathologie

    Mots-clés Pascal anglais : Carcinoma, Mammary gland, Early stage, Evaluation, Risk factor, Extension, Lymph node, Prognosis, Result, Human, Female, Malignant tumor, Mammary gland diseases, Lymphatic vessel disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0342285

    Code Inist : 002B20E02. Création : 12/09/1997.