The authors conducted a study to assess the importance of underlying liver cirrhosis in the development of hepatocellular carcinoma (HCC) and the multifactorial etiology of liver cirrhosis in chronic carriers of hepatitis B virus (HBV).
Between November 1980 and May 1990, all male hepatitis B surface antigen (HBsAg) carriers who routinely attended a clinic for asymptomatic HBV carriers at the Liver Unit of Chang-Gung Memorial Hospital, Taiwan, were enrolled in the study (n=1,506).
The authors used this cohort to investigate prospectively for liver cirrhosis and HCC at 6-month intervals by means of ultrasonography and clinical assessment.
There were 16 incident cases of HCC and 89 cases of liver cirrhosis (78 of whom were detected during follow-up) identified after an average follow-up of 7.1 years.
Subclinical liver cirrhosis diagnosed by ultrasonography was significantly associated with the risk for HCC (multivariate-adjusted relative risk (RR)=11.8,95% confidence interval (Cl) 3.9-35.8).
By multivariate analysis, the significant risk factors found for liver cirrhosis in HBsAg carriers were age, hepatitis B e antigen (HBeAg) carrier status, chronic hepatitis manifested by sustained elevated serum aminotransferase levels for =6 months, cigarette smoking, non-A blood types, and low educational levels.
Habitual alcohol drinking was not independently related to liver cirrhosis. (...)
Mots-clés Pascal : Carcinome hépatocellulaire, Epidémiologie, Cirrhose, Hépatite virale B, Virose, Infection, Asymptomatique, Homme, Facteur risque, Etude longitudinale, Tabagisme, Taiwan, Asie, Appareil digestif pathologie, Foie pathologie, Tumeur maligne
Mots-clés Pascal anglais : Hepatocellular carcinoma, Epidemiology, Cirrhosis, Viral hepatitis B, Viral disease, Infection, Asymptomatic, Human, Risk factor, Follow up study, Tobacco smoking, Taiwan, Asia, Digestive diseases, Hepatic disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0340161
Code Inist : 002B13C01. Création : 12/09/1997.