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  1. Fulltext. Prospective study of hepatocellular carcinoma and Liver cirrhosis in asymptomatic chronic hepatitis B virus carriers.

    Article - En anglais


    The authors conducted a study to assess the importance of underlying liver cirrhosis in the development of hepatocellular carcinoma (HCC) and the multifactorial etiology of liver cirrhosis in chronic carriers of hepatitis B virus (HBV).

    Between November 1980 and May 1990, all male hepatitis B surface antigen (HBsAg) carriers who routinely attended a clinic for asymptomatic HBV carriers at the Liver Unit of Chang-Gung Memorial Hospital, Taiwan, were enrolled in the study (n=1,506).

    The authors used this cohort to investigate prospectively for liver cirrhosis and HCC at 6-month intervals by means of ultrasonography and clinical assessment.

    There were 16 incident cases of HCC and 89 cases of liver cirrhosis (78 of whom were detected during follow-up) identified after an average follow-up of 7.1 years.

    Subclinical liver cirrhosis diagnosed by ultrasonography was significantly associated with the risk for HCC (multivariate-adjusted relative risk (RR)=11.8,95% confidence interval (Cl) 3.9-35.8).

    By multivariate analysis, the significant risk factors found for liver cirrhosis in HBsAg carriers were age, hepatitis B e antigen (HBeAg) carrier status, chronic hepatitis manifested by sustained elevated serum aminotransferase levels for =6 months, cigarette smoking, non-A blood types, and low educational levels.

    Habitual alcohol drinking was not independently related to liver cirrhosis. (...)

    Mots-clés Pascal : Carcinome hépatocellulaire, Epidémiologie, Cirrhose, Hépatite virale B, Virose, Infection, Asymptomatique, Homme, Facteur risque, Etude longitudinale, Tabagisme, Taiwan, Asie, Appareil digestif pathologie, Foie pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Hepatocellular carcinoma, Epidemiology, Cirrhosis, Viral hepatitis B, Viral disease, Infection, Asymptomatic, Human, Risk factor, Follow up study, Tobacco smoking, Taiwan, Asia, Digestive diseases, Hepatic disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0340161

    Code Inist : 002B13C01. Création : 12/09/1997.