The authors examined the relation between postmenopausal serum levels of testosterone and dehydroepiandrosterone sulfate (DHEAS) and subsequent risk of breast cancer in a case-control study nested within the New York University Women's Health Study cohort.
A specific objective of their analysis was to examine whether androgens had an effect on breast cancer risk independent of their effect on the biologic availability of estrogen.
A total of 130 cases of breast cancer were diagnosed prior to 1991 in a cohort of 7,054 postmenopausal women who had donated blood and completed questionnaires at a breast cancer screening clinic in New York City between 1985 and 1991.
For each case, two controls were selected, matching the case on age at blood donation and length of storage of serum specimens.
Biochemical analyses were performed on sera that had been stored at - 80°C since sampling.
The present report includes a subset of 85 matched sets, for whom at least 6 months had elapsed between blood donation and diagnosis of the case.
In univariate analysis, testosterone was positively associated with breast cancer risk (odds ratio (OR) for the highest quartile=2.7,95% confidence interval (Cl) 1.1-6.8, p<0.05, test for trend). (...)
Mots-clés Pascal : Testostérone, Déhydroépiandrostérone, Androgène, Hormone stéroïde sexuelle, Epidémiologie, Tumeur maligne, Glande mammaire, Homme, Femelle, Postménopause, Oestrogène, New York, Etats Unis, Amérique du Nord, Amérique, Glande mammaire pathologie
Mots-clés Pascal anglais : Testosterone, Dehydroepiandrosterone, Androgen, Sex steroid hormone, Epidemiology, Malignant tumor, Mammary gland, Human, Female, Postmenopause, Estrogen, New York, United States, North America, America, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0340160
Code Inist : 002B20E02. Création : 12/09/1997.