The main objective of this study was to assess whether cutaneous malignant melanoma (CMM) shows a stronger relation with the melanocytic nevi count at the site where CMM was diagnosed than with the melanocytic nevi count at other sites, stratifying by histologic CMM type, in a southern Mediterranean population.
Cases and controls were selected from a population in southern Spain in 1988-1993.
The study population included 116 incident cases with non-familial CMM (International Classification of Diseases 9th Revision (ICD-9) code 172), and 116 controls matched 1 : 1 for sex and age (±4 years).
Data were collected by personal interview, and melanocytic nevi were counted over the entire body surface by clinical skin examination performed by a dermatologist.
Crude and multiple risk factor-adjusted odds ratios and 95% confidence intervals were computed by conditional logistic regression analysis.
After adjustment by skin type, unexposed skin color, and sun exposure, CMM was found to occur significantly more frequently in individuals with a high number of melanocytic nevi at the same site where CMM originated (odds ratio (OR) for>8 nevi=12.0,95% confidence interval (Cl) 1.3-108.2).
The ability to predict the number of melanocytic nevi on different anatomic sites on CMM, but excluding the CMM cases on each corresponding site, was also examined.
A significant trend with the number of nevi on the anterior surface of thighs was found (OR for>4 nevi=4.5,95% Cl 1.4-14.9). (...)
Mots-clés Pascal : Mélanome malin, Peau, Epidémiologie, Homme, Facteur risque, Naevus naevocellulaire, Localisation, Espagne, Europe, Tumeur maligne, Peau pathologie
Mots-clés Pascal anglais : Malignant melanoma, Skin, Epidemiology, Human, Risk factor, Melanocytic nevus, Localization, Spain, Europe, Malignant tumor, Skin disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0340159
Code Inist : 002B08A. Création : 12/09/1997.