We assessed what percentage of hospitalized patients treated with intravenous antibiotics would be candidates for early switch to oral therapy, and evaluated the clinical outcomes of patients after the switch.
All hospitalized patients in whom an intravenous antibiotic was prescribed for treatment of an infection were prospectively screened to identify candidates for switch in therapy.
Of the 655 patients treated with intravenous antibiotics, 300 (46%) were candidates for a switch, and the change was implemented in 262 (40%). Of the 171 evaluable patients, the switch was associated with clinical cure in 167 (98%) and failure in 4 (2%). In hospitalized patients with infections, the duration of intravenous antibiotic therapy can be minimized with early switch to oral therapy.
This practice is associated with good patient outcome.
Mots-clés Pascal : Antibiotique, Antibactérien, Voie orale, Voie intraveineuse, Etude comparative, Efficacité traitement, Homme, Hôpital, Infection, Chimiothérapie, Traitement, Forme pharmaceutique, Prospective, Temps traitement, Observance médicamenteuse, Economie santé
Mots-clés Pascal anglais : Antibiotic, Antibacterial agent, Oral administration, Intravenous administration, Comparative study, Treatment efficiency, Human, Hospital, Infection, Chemotherapy, Treatment, Dosage form, Prospective, Processing time, Drug compliance, Health economy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0339513
Code Inist : 002B02S02. Création : 12/09/1997.