Clarifying the direct relation between total cholesterol levels and death from coronary heart disease in older persons.
The importance of total cholesterol level as a risk factor for coronary heart disease in older adults is controversial.
To determine whether findings showing that total cholesterol level is not an important risk factor for coronary heart disease in older adults are the result of inadequate adjustment for co-occurring diseases and frailty.
Multicenter, longitudinal study with 5-year follow-up for death.
4066 men and women from East Boston, Massachusetts ; Iowa and Washington counties, Iowa ; and New Haven, Connecticut.
In 1988, participants were interviewed about their health status and had blood samples taken.
Mortality follow-up was through 1992.
In analyses that included all fatal coronary heart disease events (252 deaths) and did not adjust for risk factors for coronary heart disease and measures of frailty, persons with the lowest total cholesterol levels (¾4.15 mmol/L [¾160 mg/dL]) had the highest rate of death from coronary heart disease, whereas those with elevated total cholesterol levels (=6.20 mmol/L [=240 mg/dL]) seemed to have a lower risk for death from coronary heart disease (P for trend=0.04). (...)
Mots-clés Pascal : Cardiopathie coronaire, Cholestérol, Total, Plasma sanguin, Taux, Mortalité, Pronostic, Epidémiologie, Facteur risque, Vieillard, Homme, Etude multicentrique, Etude longitudinale, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Coronary heart disease, Cholesterol, Total, Blood plasma, Rate, Mortality, Prognosis, Epidemiology, Risk factor, Elderly, Human, Multicenter study, Follow up study, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0338717
Code Inist : 002B12A03. Création : 12/09/1997.