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  1. Clarifying the direct relation between total cholesterol levels and death from coronary heart disease in older persons.

    Article - En anglais

    Background 

    The importance of total cholesterol level as a risk factor for coronary heart disease in older adults is controversial.

    Objective 

    To determine whether findings showing that total cholesterol level is not an important risk factor for coronary heart disease in older adults are the result of inadequate adjustment for co-occurring diseases and frailty.

    Design 

    Multicenter, longitudinal study with 5-year follow-up for death.

    Participants 

    4066 men and women from East Boston, Massachusetts ; Iowa and Washington counties, Iowa ; and New Haven, Connecticut.

    Measurements 

    In 1988, participants were interviewed about their health status and had blood samples taken.

    Mortality follow-up was through 1992.

    Results 

    In analyses that included all fatal coronary heart disease events (252 deaths) and did not adjust for risk factors for coronary heart disease and measures of frailty, persons with the lowest total cholesterol levels (¾4.15 mmol/L [¾160 mg/dL]) had the highest rate of death from coronary heart disease, whereas those with elevated total cholesterol levels (=6.20 mmol/L [=240 mg/dL]) seemed to have a lower risk for death from coronary heart disease (P for trend=0.04). (...)

    Mots-clés Pascal : Cardiopathie coronaire, Cholestérol, Total, Plasma sanguin, Taux, Mortalité, Pronostic, Epidémiologie, Facteur risque, Vieillard, Homme, Etude multicentrique, Etude longitudinale, Appareil circulatoire pathologie

    Mots-clés Pascal anglais : Coronary heart disease, Cholesterol, Total, Blood plasma, Rate, Mortality, Prognosis, Epidemiology, Risk factor, Elderly, Human, Multicenter study, Follow up study, Cardiovascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0338717

    Code Inist : 002B12A03. Création : 12/09/1997.