The objective of this study was to update the registry of women in the Netherlands with clear cell adenocarcinoma (CCAC) of the cervix or vagina with or without intrauterine exposure to diethylstilbestrol (DES).
From a nationwide search in PALGA, the automated pathology registry in the Netherlands, data were gathered on women with CCAC born after 1947.
Information obtained from the clinical files of the patients included reported exposure to DES, patterns of complaints previous to diagnosis, the current status of the patients, and the results of cytopathologic examinations previous to histopathologic diagnosis.
After review of the histopathologic slides, the specific pathologic characteristics of CCAC were determined.
The age distribution of women born after 1947 was compared with that of women born before 1947.
Information about possible exposure to DES during pregnancy was available for 73 of 88 women with CCAC born after 1947.
Exposure to DES was reported for 47 (64%) of these women.
The DES medication was most often reported as having started before the 18th week of pregnancy.
Cytopathologic examination was informative in 81% of the cases of CCAC of the cervix, but only in 41% of the cases of CCAC of the vagina.
Most patients had Stage I or II tumors at diagnosis.
Tumor Stage III and IV and a high grade of nuclear atypia were related to unfavorable outcome. (...)
Mots-clés Pascal : Diéthylstilbestrol, Toxicité, Long terme, Adénocarcinome, Carcinome cellule claire, Vagin, Col utérus, Homme, Femelle, Pays Bas, Europe, Incidence, Classe âge, Epidémiologie, Tumeur maligne
Mots-clés Pascal anglais : Diethylstilbestrol, Toxicity, Long term, Adenocarcinoma, Clear cell carcinoma, Vagina, Uterine cervix, Human, Female, Netherlands, Europe, Incidence, Age distribution, Epidemiology, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0338468
Code Inist : 002B02U06. Création : 12/09/1997.