Nutrition early in life may influence adult mortality.
The fetal-origins hypothesis suggests that nourishment before birth and during the individual's infancy programs the development of risk factors for several important diseases of middle and old age.
The present study was designed to evaluate the impact of extreme nutritional deprivation in utero and during infancy and early childhood on mortality in later life.
The authors analyzed the survival of the cohorts born in Finland during the severe 1866-1868 famine and during the 5 years immediately preceding and 5 years immediately following the famine.
The study included 331,932 individuals born prior to the famine, 161,744 born during the famine, and 323,321 born after the famine.
The authors assessed survival by cohorts from birth to age 17 years and from age 17 to 40,60, and 80 years, as well as average length of life after age 80 years.
Survival from birth to age 17 years was significantly lower in cohorts born before and during the famine than in the cohorts born after the famine (males, 0.566 vs. 0.671, a difference of 0.105 (95% confidence interval (Cl) 0.102-0.108) ; females, 0.593 vs. 0.692, a difference of 0.099 (95% Cl 0.096-0.102)). At subsequent ages, including old age, mortality was practically identical in the famine-born cohorts and in the five cohorts born before and after the crisis. (...)
Mots-clés Pascal : Mortalité, Epidémiologie, Vieillard, Homme, Expérience infantile, Famine, Hypotrophie foetale, Facteur risque, Etude cohorte, Nutrition, Finlande, Europe, Gestation pathologie, Foetus pathologie, Année naissance, Enfance
Mots-clés Pascal anglais : Mortality, Epidemiology, Elderly, Human, Infantile experience, Famine, Fetal hypotrophy, Risk factor, Cohort study, Nutrition, Finland, Europe, Pregnancy disorders, Fetal diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0338450
Code Inist : 002B30A01A2. Création : 12/09/1997.