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  1. Fulltext. Bovine spongiform encephalopathy (BSE) : Causes and consequences of a common source epidemic.

    Article - En anglais


    Bovine spongiform encephalopathy (BSE) is a transmissible spongiform encephalopathy (TSE) or prion disease of cattle first recognized in 1986 in the United Kingdom, where it produced a common source epidemic that peaked in January 1993 and has subsided markedly since that time.

    The epidemic began simultaneously at many geographic locations and was traced to contamination of meat and bone meal (MBM), a dietary supplement prepared from rendering of slaughterhouse offal.

    It appears that the epidemic was initiated by the presence of the agent of scrapie (a long-standing TSE of sheep) that was first transmitted to cattle, beginning in the early 1980s, when most rendering plants abandoned the use of organic solvents in the preparation of MBM.

    The epidemic was probably accelerated by the recycling of infected bovine tissues prior to the recognition of BSE.

    To terminate the epidemic, a prohibition on the feeding of ruminant-derived protein to ruminants was introduced in the United Kingdom in July 1988.

    The ruminant feed ban accounts for the decline of the epidemic after an interval of about 5 years, approximately equivalent to the average incubation period of BSE.

    Relatively few cases of BSE have occurred in cattle born after 1993, and it is predicted that the epidemic will terminate about the year 2000 based on an extrapolation of the present declining curve. (...)

    Mots-clés Pascal : Encéphalopathie spongiforme, Bovin, Artiodactyla, Ungulata, Mammalia, Vertebrata, Epidémie, Royaume Uni, Europe, Bétail, Encéphalopathie spongiforme Creutzfeldt Jakob, Infection, Homme, Aliment pour animal, Viande boeuf, Contamination, Animal, Prévision, Législation, Prion, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative, Article synthèse

    Mots-clés Pascal anglais : Spongiform encephalopathy, Bovine, Artiodactyla, Ungulata, Mammalia, Vertebrata, Epidemic, United Kingdom, Europe, Livestock, Creutzfeldt Jakob disease, Infection, Human, Feed, Beef, Contamination, Animal, Forecasting, Legislation, Prion, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease, Review

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0338447

    Code Inist : 002B30A02A. Création : 12/09/1997.