Resistance to activated protein C and Arg 506 Gln factor V mutation are uncommon in eastern Asian populations.
We investigated the prevalence of the factor V (FV) Arg 506 GIn mutation in healthy subjects from three eastern Asian countries (Japan, n=270 ; China, n=113 ; and Korea, n=93) and in 26 Japanese patients showing venous thromboembolic events.
The patients were also examined for activated protein C (APC) resistance by using the Coatest APC resistance kit.
The FV mutation was investigated by polymerase chain reaction and restricted enzyme digestion with Mn/I RFLP assay of the FV gene.
None of the patients showed APC resistance, while all subjects examined were homozygous for Arg at position 506 of the FV gene.
Our results imply that FV mutation and APC resistance contribute little to venous thrombotic diseases in eastern Asia.
Mots-clés Pascal : Résistance, Protein C (activated), Serine endopeptidases, Peptidases, Hydrolases, Enzyme, Prévalence, Epidémiologie, Japon, Asie, Chine, Corée, Thrombose, Veine, Thromboembolie, Complication, Homme, Hémopathie, Coagulopathie, Maladie héréditaire, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Veine pathologie, Facteur V Leiden
Mots-clés Pascal anglais : Resistance, Protein C (activated), Serine endopeptidases, Peptidases, Hydrolases, Enzyme, Prevalence, Epidemiology, Japan, Asia, China, Korea, Thrombosis, Vein, Thromboembolism, Complication, Human, Hemopathy, Coagulopathy, Genetic disease, Cardiovascular disease, Vascular disease, Venous disease, Factor V Leiden
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0337176
Code Inist : 002B19C. Création : 12/09/1997.