The elimination of bêta-hexachlorocyclohexane (bêta-HCH) in humans was investigated in a group of 40 former workers of a lindane-producing plant by analyzing at least 2 blood specimens (3 specimens in 3 workers) from different time points.
Assuming a first-order kinetic model for excretion, the median half-life of bêta-HCH is 7.2 yr calculated by concentrations in whole blood and 7.6 yr calculated by concentrations in extractable lipids.
In univariate analyses an influence of age, percent body fat, and liver disease (additionally in whole blood an influence of contents of extractable lipids) on clearance was observed.
All factors show a positive correlation with half-life.
According to a multiple regression model, influence of percent body fat calculated according to Deurenberg et al. (1991) is an important covariate in the description of the variations of the clearance rate (calculated on the basis of extractable lipids) of bêta-HCH.
The data support the assumption of first-order kinetics.
Mots-clés Pascal : Toxicocinétique, Cinétique, Elimination, Pesticide, Insecticide, Lindane, Organochloré, Homme, Médecine travail, Exposition professionnelle, Analyse statistique, Covariable, Tissu adipeux
Mots-clés Pascal anglais : Toxicokinetics, Kinetics, Elimination, Pesticides, Insecticide, Lindane, Organochlorine compounds, Human, Occupational medicine, Occupational exposure, Statistical analysis, Covariate, Adipose tissue
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0328868
Code Inist : 002B03G. Création : 12/09/1997.