Much remains to be clarified in the apparently protective effect of moderate alcohol use against coronary heart disease risk.
Insulin levels are positively associated with coronary heart disease risk, so recent reports of decreased insulin sensitivity among nondrinkers and lower fasting insulin levels with increasing alcohol intake suggest the possibility that insulin may play a role.
Between 1987 and 1991, the authors examined fasting insulin concentrations and the empiric fasting insulin resistance index in relation to reported alcohol intake (mean, 15.3 g/day ; standard deviation, 19.6 ; range, 0-120.6) and potential confounders.
The latter included age, obesity, fat distribution, smoking, energy, saturated fat intake, antihypertensive medication, and physical activity.
Participants in this cross-sectional analysis were 938 nondiabetic men from the Boston, Massachusetts, area who were part of the Normative Aging Study.
Unadjusted fasting insulin levels were significantly different (p=0.008) between categories of alcohol intake, as were fasting insulin resistance index values (p=0.01).
After adjustment for potential confounders, analysis revealed that subjects consuming moderate amounts of alcohol had the lowest fasting insulin and fasting insulin resistance index values.
Compared with values from moderate drinkers, fasting insulin resistance index values were higher in those subjects reporting no alcohol intake (p=0.011), low intake (p=0.004), and high intake (p=0. (...)
Mots-clés Pascal : Consommation, Ethanol, Epidémiologie, Insuline, Taux, Cardiopathie coronaire, Homme, Facteur risque, Etats Unis, Amérique du Nord, Amérique, Prévention, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Consumption, Ethanol, Epidemiology, Insulin, Rate, Coronary heart disease, Human, Risk factor, United States, North America, America, Prevention, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0325514
Code Inist : 002B12A03. Création : 12/09/1997.