The relation of intakes of specific fatty acids and the risk of coronary heart disease was examined in a cohort of 21,930 smoking men aged 50-69 years who were initially free of diagnosed cardiovascular disease.
All men participated in the Finnish Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study and completed a detailed and validated dietary questionnaire at baseline.
After 6.1 years of follow-up from 1985-1988, the authors documented 1,399 major coronary events and 635 coronary deaths.
After controlling for age, supplement group, several coronary risk factors, total energy, and fiber intake, the authors observed a significant positive association between the intake of trans-fatty acids and the risk of coronary death.
For men in the top quintile of trans-fatty acid intake (median=6.2 g/day), the multivariate relative risk of coronary death was 1.39 (95% confidence interval (Cl) 1.09-1.78) (p for trend=0.004) as compared with men in the lowest quintile of intake (median=1.3 g/day).
The intake of omega-3 fatty acids from fish was also directly related to the risk of coronary death in the multivariate model adjusting also for trans-saturated and cis-monounsaturated fatty acids (relative risk (RR)=1.30,95% Cl 1.01-1.67) (p for trend=0.06 for men in the highest quintile of intake compared with the lowest). (...)
Mots-clés Pascal : Cardiopathie coronaire, Mortalité, Epidémiologie, Consommation alimentaire, Comportement alimentaire, Lipide, Acide gras, Acide gras saturé, Acide gras n-3, Acide gras monoinsaturé, Acide gras polyinsaturé, Stéréoisomère trans, Homme, Finlande, Europe, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Coronary heart disease, Mortality, Epidemiology, Food intake, Feeding behavior, Lipids, Fatty acids, Saturated fatty acid, n-3 fatty acid, Monounsaturated fatty acid, Polyunsaturated fatty acid, Trans stereoisomer, Human, Finland, Europe, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0325511
Code Inist : 002B12A03. Création : 12/09/1997.