Does age at natural menopause affect mortality from ischemic heart disease ?
We examined the relationship between age at natural menopause and mortality of ischemic heart disease in 19,309 Norwegian postmenopausal women.
A total of 2767 fatal infarctions occurred during 29 years of follow up.
Overall, a relatively weak inverse relationship was seen with approximately 10% lower ischemic heart disease mortality in women aged =47 years at the menopause compared to women with an early menopause (<44 years).
Risk estimates were similar for women aged 47 and more at menopause.
However, the inverse relationship was stronger and statistically significant (p=0.01) in women aged less than 70 years.
In this group of women, we observed a nearly 60% reduction in the ischemic heart disease mortality in women with a late menopause (=53 years) compared to women aged<44 years at menopause (mortality rate ratio=0.42 ; 95% confidence interval 0.25-0.72).
This protective effect of a late menopause is reduced with advancing age, however, and is of minor significance in the age groups where the great proportion of the ischemic heart disease deaths occur.
Mots-clés Pascal : Ischémie, Myocarde, Mortalité, Epidémiologie, Femme, Homme, Ménopause, Age, Norvège, Europe, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Cardiopathie coronaire, Myocarde pathologie
Mots-clés Pascal anglais : Ischemia, Myocardium, Mortality, Epidemiology, Woman, Human, Menopause, Age, Norway, Europe, Cardiovascular disease, Vascular disease, Coronary heart disease, Myocardial disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0323757
Code Inist : 002B12A03. Création : 12/09/1997.