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  1. Does age at natural menopause affect mortality from ischemic heart disease ?

    Article - En anglais

    We examined the relationship between age at natural menopause and mortality of ischemic heart disease in 19,309 Norwegian postmenopausal women.

    A total of 2767 fatal infarctions occurred during 29 years of follow up.

    Overall, a relatively weak inverse relationship was seen with approximately 10% lower ischemic heart disease mortality in women aged =47 years at the menopause compared to women with an early menopause (<44 years).

    Risk estimates were similar for women aged 47 and more at menopause.

    However, the inverse relationship was stronger and statistically significant (p=0.01) in women aged less than 70 years.

    In this group of women, we observed a nearly 60% reduction in the ischemic heart disease mortality in women with a late menopause (=53 years) compared to women aged<44 years at menopause (mortality rate ratio=0.42 ; 95% confidence interval 0.25-0.72).

    This protective effect of a late menopause is reduced with advancing age, however, and is of minor significance in the age groups where the great proportion of the ischemic heart disease deaths occur.

    Mots-clés Pascal : Ischémie, Myocarde, Mortalité, Epidémiologie, Femme, Homme, Ménopause, Age, Norvège, Europe, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Cardiopathie coronaire, Myocarde pathologie

    Mots-clés Pascal anglais : Ischemia, Myocardium, Mortality, Epidemiology, Woman, Human, Menopause, Age, Norway, Europe, Cardiovascular disease, Vascular disease, Coronary heart disease, Myocardial disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0323757

    Code Inist : 002B12A03. Création : 12/09/1997.