logo BDSP

Base documentaire

  1. The impact of stage and histology on the long-term clinical course of 163,808 patients with breast carcinoma.

    Article - En anglais


    Stage and histologic type have a significant impact on the long term clinical course of breast carcinoma.

    Clinical course is governed by two components : likelihood of cure and median tumor-related survival time among uncured patients.

    Estimates of these components can be derived only by using survival models that incorporate cured fraction as a specific parameter.


    The prognostic value of stage and histologic type was determined for 163,808 patients with breast carcinoma using the log normal and log logit cure-based survival models.

    Follow-up ranged from 1 month to 19 years and was obtained from the SEER Program.


    In approximate terms, ductal carcinoma was diagnosed in 70% of the patients, with estimated cured fractions of 2/3 and 1/3 for local, and regional disease, respectively.

    Estimates of median survival times for uncured patients were 10 and 5 years.

    Findings were similar for patients with tumors of miscellaneous histologic types.

    For patients with medullary carcinoma, cured fractions were relatively high at 82% and 64%, but median survival times were relatively short at 4 and 3 years.

    Corresponding values for patients with invasive comedo carcinoma were 82% and 50%, with median survival times of 6 and 4 years.

    For patients with mucinous, lobular, and ductolobular carcinomas, parametric analysis gave inconsistent estimates of cured fraction, but findings suggested unusually long tumor-related survival times.



    Mots-clés Pascal : Carcinome, Glande mammaire, Pronostic, Survie, Long terme, Type histologique, Stade clinique, Méthode paramétrique, Méthode statistique, Epidémiologie, Etude longitudinale, Homme, Femelle, Tumeur maligne, Glande mammaire pathologie

    Mots-clés Pascal anglais : Carcinoma, Mammary gland, Prognosis, Survival, Long term, Histological type, Clinical stage, Parametric method, Statistical method, Epidemiology, Follow up study, Human, Female, Malignant tumor, Mammary gland diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0321791

    Code Inist : 002B20E02. Création : 12/09/1997.