Stage and histologic type have a significant impact on the long term clinical course of breast carcinoma.
Clinical course is governed by two components : likelihood of cure and median tumor-related survival time among uncured patients.
Estimates of these components can be derived only by using survival models that incorporate cured fraction as a specific parameter.
The prognostic value of stage and histologic type was determined for 163,808 patients with breast carcinoma using the log normal and log logit cure-based survival models.
Follow-up ranged from 1 month to 19 years and was obtained from the SEER Program.
In approximate terms, ductal carcinoma was diagnosed in 70% of the patients, with estimated cured fractions of 2/3 and 1/3 for local, and regional disease, respectively.
Estimates of median survival times for uncured patients were 10 and 5 years.
Findings were similar for patients with tumors of miscellaneous histologic types.
For patients with medullary carcinoma, cured fractions were relatively high at 82% and 64%, but median survival times were relatively short at 4 and 3 years.
Corresponding values for patients with invasive comedo carcinoma were 82% and 50%, with median survival times of 6 and 4 years.
For patients with mucinous, lobular, and ductolobular carcinomas, parametric analysis gave inconsistent estimates of cured fraction, but findings suggested unusually long tumor-related survival times.
Mots-clés Pascal : Carcinome, Glande mammaire, Pronostic, Survie, Long terme, Type histologique, Stade clinique, Méthode paramétrique, Méthode statistique, Epidémiologie, Etude longitudinale, Homme, Femelle, Tumeur maligne, Glande mammaire pathologie
Mots-clés Pascal anglais : Carcinoma, Mammary gland, Prognosis, Survival, Long term, Histological type, Clinical stage, Parametric method, Statistical method, Epidemiology, Follow up study, Human, Female, Malignant tumor, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0321791
Code Inist : 002B20E02. Création : 12/09/1997.