This study describes the functioning of primary care patients with major depressive disorder, the relationship of medical comorbidity to functional status, and the effects of depression-specific treatment on functional status after 8 months.
Patients were randomized to a protocol intervention (nortriptyline hydrochloride or interpersonal psychotherapy) or to usual care with the patient's physician in a clinical trial of primary care treatments of depression.
Their functional status was evaluated using the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) and the Global Assessment Scale.
Medical comorbidity was assessed with the Duke Severity of Illness Checklist.
The Hamilton Rating Scale for Depression and Beck Depression Inventory were used to measure depressive severity.
Assessments were conducted at baseline and at 1,2,4, and 8 months after randomization.
At baseline, patients reported substantial impairments in the functional domains as assessed by the SF-36 and Global Assessment Scale.
Severity of general medical illness and depression were not correlated.
Greater medical comorbidity was associated with diminished physical, but not psychological, functioning.
Mean scores on SF-36 scales and the Global Assessment Scale improved significantly during the 8 months of follow-up. (...)
Mots-clés Pascal : Etat dépressif, Aide diagnostic, Anamnèse, Protocole thérapeutique, Relation médecin malade, Facteur prédictif, Efficacité traitement, Randomisation, Homme, Système nerveux pathologie, Psychopathologie
Mots-clés Pascal anglais : Depression, Diagnostic aid, Anamnesis, Therapeutic protocol, Physician patient relation, Predictive factor, Treatment efficiency, Randomization, Human, Nervous system diseases, Psychopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0321522
Code Inist : 002B18C07A. Création : 12/09/1997.