This cohort study examined the relationship between newly prescribed NSAIDs (none in the previous six months) and upper gastrointestinal hemorrhage and perforation in Tayside, Scotland.
Exposure was classified by prescription duration.
The study population consisted of the population of Tayside.
A Comparator Group was chosen at random (within age and sex strata).
Two hundred re-sampled comparator groups were created.
Statistical analyses were carried out by Poisson regression (repeated for each of the re-samples).
The analyses controlled for age, sex, prior hospitalization for upper gastrointestinal events, prior endoscopy, and the use of ulcer healing drugs.
There were 78,191 subjects in the NSAID group, and 78,207 in each of the comparator groups.
The increased risk with NSAIDs was only apparent for subjects without a history of upper gastrointestinal events ; univariate rate ratio=2.76 (1.90,4.01).
The final, re-sampled estimate of NSAID risk was rate ratio=2.48 (1.87,3.29).
Mots-clés Pascal : Antiinflammatoire non stéroïde, Toxicité, Hémorragie, Gastrointestinal, Perforation, Intestin, Epidémiologie, Homme, Ecosse, Grande Bretagne, Royaume Uni, Europe, Etude cohorte, Appareil digestif pathologie, Estomac pathologie, Intestin pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Non steroidal antiinflammatory agent, Toxicity, Hemorrhage, Gastrointestinal, Perforation, Gut, Epidemiology, Human, Scotland, Great Britain, United Kingdom, Europe, Cohort study, Digestive diseases, Gastric disease, Intestinal disease, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0320772
Code Inist : 002B02U04. Création : 12/09/1997.