logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. A liability theory of disease : the foundation of cell population pathology.

    Article - En anglais

    Within a homogeneous population of cells, the tendency of individual cells to become diseased is not'homogeneous'As a general concept of disease, the'liability theory'describes such a tendency (cell liability) as a quantitative characteristic following a continuous distribution.

    This suggests that there are always some cells that are more liable than the rest and that the liability values of cells or liability-associated cell characteristics can be assessed quantitatively.

    By defining the more or extremely liable cells through a critical value or'threshold'the liability theory hypothesizes that these cells may play a significant role in determining or affecting the overall disease liability of a cell population ; the more such cells are present, the more liable the cell population is, as a whole, to disease.

    Furthermore, it proposes that the origin and development of disease may be fundamentally relevant to this kind of intrapopulational variation in cell liability.

    The liability theory attempts to provide a theoretical framework for studying the'cell population'mechanism of disease, or cell population pathology.

    Also, it may serve as a working model for analysis and assessment of cell population liabilities for various diseases.

    Mots-clés Pascal : Population cellulaire, Etiologie, Hypothèse, Maladie, Mécanisme action, Liaison coordination, Homme

    Mots-clés Pascal anglais : Cell population, Etiology, Hypothesis, Disease, Mechanism of action, Coordination bond, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0320455

    Code Inist : 002B30A01A2. Création : 12/09/1997.