logo BDSP

Base documentaire

  1. A liability theory of disease : the foundation of cell population pathology.

    Article - En anglais

    Within a homogeneous population of cells, the tendency of individual cells to become diseased is not'homogeneous'As a general concept of disease, the'liability theory'describes such a tendency (cell liability) as a quantitative characteristic following a continuous distribution.

    This suggests that there are always some cells that are more liable than the rest and that the liability values of cells or liability-associated cell characteristics can be assessed quantitatively.

    By defining the more or extremely liable cells through a critical value or'threshold'the liability theory hypothesizes that these cells may play a significant role in determining or affecting the overall disease liability of a cell population ; the more such cells are present, the more liable the cell population is, as a whole, to disease.

    Furthermore, it proposes that the origin and development of disease may be fundamentally relevant to this kind of intrapopulational variation in cell liability.

    The liability theory attempts to provide a theoretical framework for studying the'cell population'mechanism of disease, or cell population pathology.

    Also, it may serve as a working model for analysis and assessment of cell population liabilities for various diseases.

    Mots-clés Pascal : Population cellulaire, Etiologie, Hypothèse, Maladie, Mécanisme action, Liaison coordination, Homme

    Mots-clés Pascal anglais : Cell population, Etiology, Hypothesis, Disease, Mechanism of action, Coordination bond, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0320455

    Code Inist : 002B30A01A2. Création : 12/09/1997.