Elevated serum lipoprotein (a) [Lp (a) ] concentrations have been demonstrated to be associated with cardiovascular diseases due to premature atherosclerosis.
However, the association of Lp (a) phenotypes with the development of these diseases remains largely unexplored.
We analyzed the population-based frequencies of serum Lp (a) phenotypes in 269 Japanese children aged 8-13 years in one community.
According to the different apolipoprotein (a) [apo (a) ] electrophoretic mobilities, Lp (a) was classified into seven single-band and respective double-band phenotypes.
Each individual expressed a single (homozygotic) or a double band (heterozygotic).
The serum Lp (a) concentration frequency distribution was skewed toward lower levels with a mean ± SD of 15.5 ± 18.0 mg/dl and a median of 11.0 mg/dl.
The Lp (a) phenotype frequencies revealed that the frequency of double-band phenotype expression (55%) was higher than that of single bands (44%) and that the frequency of phenotypes representative of low molecular weight apo (a) was very low (2%). The mean serum Lp (a) concentration of the double-band-expressing subjects was higher than that of subjects with the single-band phenotype (20.1 ± 19.9 vs. 10.5 ± 15.9 mg/dl, p<0.01). (...)
Mots-clés Pascal : Athérosclérose, Complication, Appareil circulatoire pathologie, Valeur prédictive, Facteur risque, Phénotype, Lipoprotéine a, Etude cohorte, Enfant, Homme, Japon, Asie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Atherosclerosis, Complication, Cardiovascular disease, Predictive value, Risk factor, Phenotype, Lipoprotein a, Cohort study, Child, Human, Japan, Asia, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0320255
Code Inist : 002B12B01. Création : 12/09/1997.