To evaluate the hypothesis that fenoterol or all inhaled bêta-agonists caused an epidemic of asthma mortality in New Zealand from the late 1970s to the mid-1980s, we examined trends from 1970 to 1992 in per capita sales of inhaled fenoterol, inhaled bêta-agonists, and asthma mortality in New Zealand and nine other countries that marketed fenoterol.
During the last two decades, there has been a large and widespread increase in sales of inhaled bêta-agonists, including fenoterol.
Asthma mortality in most countries, however, has been relatively stable.
Only New Zealand experienced an epidemic of asthma mortality.
In addition, sales rates of fenoterol similar in magnitude to those in New Zealand near the peak of the epidemic also occurred in Belgium, Austria, and Germany, while asthma mortality in these countries remained low.
Also, sales rates of all bêta-agonists in Australia were similar to those in New Zealand, but no epidemic of asthma mortality occurred in Australia.
Therefore, the difference between asthma mortality rates in New Zealand and other countries is not explained by differences in per capita sales of fenoterol or all bêta-agonists.
Within New Zealand, the beginning and end of the epidemic correlated with a rise and fall in sales of all bêta-agonists, including fenoterol.
From 1980 to 1989, however, sales of fenoterol and all bêta-agonists doubled in New Zealand while asthma mortality declined by 40%. (...)
Mots-clés Pascal : Fénotérol, Agoniste, Récepteur bêta2-adrénergique, Bronchodilatateur, Antiasthmatique, Asthme, Toxicité, Epidémiologie, Tendance, Vente, Mortalité, Inhalation, Nouvelle Zélande, Océanie, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Allergie, Immunopathologie, International, Homme
Mots-clés Pascal anglais : Fenoterol, Agonist, bêta2-Adrenergic receptor, Bronchodilator, Antiasthma agent, Asthma, Toxicity, Epidemiology, Trend, Sales, Mortality, Inhalation, New Zealand, Oceania, Respiratory disease, Obstructive pulmonary disease, Allergy, Immunopathology, International, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0320034
Code Inist : 002B02U07. Création : 12/09/1997.