Breast cancer is a morphologically and genetically heterogeneous disease.
The Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute provides the large number of cases necessary to study individual histologic types of female invasive breast cancer that for practical reasons are otherwise unattainable.
Attention was specifically focused on 4082 cases of mucinous adenocarcinoma and 139,154 cases of infiltrating duct carcinoma identified for the years 1973-1990.
Life table analyses were conducted to compare survival by histologic type using death due to breast cancer as the outcome ; Cox proportional hazards analysis was used to adjust for important covariates.
Findings were that women diagnosed with mucinous adenocarcinoma have a rate of mortality due to breast cancer that is 0.38 that of the rate of women diagnosed with infiltrating duct carcinoma (95% confidence interval 0.34-0.42).
We conclude that histologic type is important to consider in the prognosis and treatment of women diagnosed with breast cancer.
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Survie, Mortalité, Adénocarcinome mucineux, Type histologique, Tumeur infiltrante, Epidémiologie, Homme, Femelle, Etats Unis, Amérique du Nord, Amérique, Glande mammaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Survival, Mortality, Mucinous adenocarcinoma, Histological type, Infiltrating tumor, Epidemiology, Human, Female, United States, North America, America, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0318762
Code Inist : 002B20E02. Création : 12/09/1997.