The low incidence of coronary heart disease (CHD) in premenopausal women is partly ascribed to protection by endogenous estrogen production.
As a consequence, we hypothesized that premenopausal women with low endogenous estrogen production or high androgen production might be at increased risk for CHD.
We studied the relationship between urinary sex hormone excretions and CHD risk by means of a nested case-referent study within a cohort of premenopausal (ages 40-49 yrs) women (n=11,284).
This cohort was formed at a breast cancer screening project in 1982-1986 (The Diagnostisch Onderzoek Mammacarcinoom [DOM] Project).
Baseline data included self-administered questionnaires and anthropometric measurements.
At the time of screening the women were instructed to collect an ovemight urine sample on day 22 of three separate cycles.
These urine samples were stored at - 20°C. Up to June 1991,45 subjects were admitted to local hospitals on diagnosis of CHD (29 with myocardial infarction, and 16 with angiographically confirmed coronary disease).
Referents were sampled from the cohort, matched for age and year of screening in a 1 : 3 ratio.
In a follow-up study, menopausal state of the subjects was assessed yearly by mailed questionnaires.
Urinary excretions of estrone-glucuronide, pregnanediol-glucuronide, and testosterone-glucuronide adjusted by creatinine were similar for cases and referents. (...)
Mots-clés Pascal : Cardiopathie coronaire, Epidémiologie, Facteur risque, Homme, Femelle, Préménopause, Hormone stéroïde sexuelle, Urine, Oestrogène, Progestatif, Pays Bas, Europe, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Coronary heart disease, Epidemiology, Risk factor, Human, Female, Premenopause, Sex steroid hormone, Urine, Estrogen, Progestagen, Netherlands, Europe, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0318761
Code Inist : 002B12A03. Création : 12/09/1997.