Among genital human papillomaviruses (HPVs), the so-called high-risk (HPV 16,18, etc.) and intermediate-risk (HPV 58, etc.) viruses are believed to be etiologically associated with cervical cancer.
To estimate the extent of infection with common HPVs among Japanese females, we examined 328 sera from healthy donors (201) and patients with cervical intraepithelial neoplasia (CIN) (22), cervical cancer (67), and condyloma acuminatum (CA) (38) for IgG antibodies against L1 capsid protein by enzyme-linked immunosorbent assay using virus-like particles of HPVs 16,18,58 and 6b (low-risk) as antigens.
Antibodies recognizing conformational epitopes were found in the sera from both the patients and the healthy donors.
The prevalences of anti-HPV 16,18, and 58 antibodies in the sera from the patients with CIN (45%) and cervical cancer (49%), and that of anti-HPV 6b in the sera from the patients with CA (55%), were significantly higher than those in the sera from the agematched healthy donors (12%, 14%, and 23%, respectively).
Anti-HPV 16 was not found in some of the sera from patients with HPV 16-DNA positive CIN or cervical cancer, suggesting that HPV infection may not always induce production of anti-capsid antibodies or that the level of antibodies may not always be maintained until development of CIN or cancer.
Some of the sera contained antibodies against more than one type of HPV, suggesting that the donors had been infected with different HPVs. (...)
Mots-clés Pascal : Tumeur maligne, Col utérus, Dysplasie, Papillomavirus humain 16, Papillomavirus, Papovaviridae, Virus, Papillomavirus humain 18, Prévalence, Sérologie, Anticorps, Nucléocapside, Japon, Asie, Epidémiologie, Exploration immunologique, Virose, Infection, Homme, Appareil génital femelle pathologie, Col utérus pathologie, Lésion précancéreuse, Papillomavirus humain 58, Papillomavirus humain 6b
Mots-clés Pascal anglais : Malignant tumor, Uterine cervix, Dysplasia, Human papillomavirus 16, Papillomavirus, Papovaviridae, Virus, Human papillomavirus 18, Prevalence, Serology, Antibody, Nucleocapsid, Japan, Asia, Epidemiology, Immunological investigation, Viral disease, Infection, Human, Female genital diseases, Uterine cervix diseases, Premalignant lesion
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0318162
Code Inist : 002B20C02. Création : 12/09/1997.