Argatroban in the treatment of radiation injury of the hand : A case report.
This case report describes a 36-year-old man who accidentally exposed his right hand to ionizing radiation with an energy of 50 kV, 200 mA (estimated radiation dose, 100 to 200 Gy).
The short-and long-term effects of exposure to radiation are presented.
Treatment was delayed until day 20, and therapeutic interventions thereafter were directed mainly toward the prevention of infection and vascular damage caused by the radiation.
The antithrombotic agent argatroban was used to inhibit thrombus formation and facilitate peripheral blood flow, thereby preventing the extension of a necrotic lesion.
Macroscopic changes are chronologically reviewed.
Although the patient is in good general condition after the accident, he is still under observation for the potential occurrence of delayed afteref-fects of the radiation.
Mots-clés Pascal : Argatroban, Inhibiteur thromboagrégation, Chimiothérapie, Traitement, Prévention, Nécrose, Thrombus, Main, Irradiation ionisante, Irradiation RX, Toxicité, Exposition professionnelle, Médecine travail, Accident travail, Etude cas, Homme, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Argatroban, Antiplatelet agent, Chemotherapy, Treatment, Prevention, Necrosis, Thrombus, Hand, Ionizing irradiation, X ray irradiation, Toxicity, Occupational exposure, Occupational medicine, Occupational accident, Case study, Human, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0317956
Code Inist : 002B02G. Création : 12/09/1997.