The authors examined the association between age at menarche, menstrual cycle characteristics between ages 28 and 32 years, and peri-and postmenopausal fracture risk in a cohort of 874 women who prospectively recorded menstrual cycle data for at least 5 years from their early 20s through their menopause.
Fracture history was obtained with a self-administered questionnaire.
The mean age of respondents at the time the questionnaire was completed was 73 years.
Wrist fracture (n=62) risk increased with increasing age at menarche (odds ratio 3.3,95% confidence interval 1.7-6.2) for menarche age=14 years compared with 12-13 years) and increasing mean cycle length at age 28-32 (odds ratio 2.2,95% confidence interval 1.0-4.9) for>30.5 days compared with 26.6-30.5 days).
Similar results were seen in analyses of the combined wrist, hip, or vertebral fracture group (n=92).
These prospectively recorded menstrual diary data indicate that age at menarche and menstrual cycle patterns may have a long-term association with fracture risk, with effects lasting into the postmenopausal years.
Mots-clés Pascal : Ostéoporose, Fracture, Epidémiologie, Homme, Femelle, Première menstruation, Cycle menstruel, Ménopause, Facteur risque, Minnesota, Etats Unis, Amérique du Nord, Amérique, Système ostéoarticulaire pathologie, Ostéopathie, Traumatisme
Mots-clés Pascal anglais : Osteoporosis, Fracture, Epidemiology, Human, Female, Menarche, Menstrual cycle, Menopause, Risk factor, Minnesota, United States, North America, America, Diseases of the osteoarticular system, Bone disease, Trauma
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0315884
Code Inist : 002B16H. Création : 12/09/1997.