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  1. Fulltext. Gender gap in cystic fibrosis mortality.

    Article - En anglais


    The authors conducted the largest study to date of survival in cystic fibrosis.

    The study cohort consisted of all patients with cystic fibrosis seen at Cystic Fibrosis Foundation-accredited care centers in the United States between 1988 and 1992 (n=21,047), or approximately 85% of all US patients diagnosed with cystic fibrosis.

    Cox proportional hazards regression analysis was used to compare the age-specific mortality rates of males and females and to identify risk factors serving as potential explanatory variables for the gender-related difference in survival.

    Among the subjects 1-20 years of age, females were 60% more likely to die than males (relative risk=1.6,95% confidence interval 1.4-1.8).

    Outside this age range, male and female survival rates were not significantly different.

    The median survival for females was 25.3 years and for males was 28.4 years.

    Nutritional status, pulmonary function, and airway microbiology at a given age were strong predictors of mortality at subsequent ages.

    Nonetheless, differences between the genders in these parameters, as well as pancreatic insufficiency, age at diagnosis, mode of presentation, and race, could not account for the poorer survival among females.

    Even after adjustment for all these potential risk factors, females in the age range 1-20 years remained at greater risk for death (relative risk=1.6,95% confidence interval 1.2-2.1). (...)

    Mots-clés Pascal : Mucoviscidose, Mortalité, Homme, Epidémiologie, Sexe, Survie, Age, Facteur risque, Etats Unis, Amérique du Nord, Amérique, Appareil respiratoire pathologie, Appareil digestif pathologie, Pancréas pathologie, Maladie héréditaire, Métabolisme pathologie

    Mots-clés Pascal anglais : Cystic fibrosis, Mortality, Human, Epidemiology, Sex, Survival, Age, Risk factor, United States, North America, America, Respiratory disease, Digestive diseases, Pancreatic disease, Genetic disease, Metabolic diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0315883

    Code Inist : 002B13C03. Création : 12/09/1997.