To assess the measurement error by using single exposure measurement in epidemiologic studies, reproducibility of urinary bêta2-microglobulin and cadmium excretion was evaluated among persons exposed to environmental cadmium.
We measured urinary bêta2-microglobulin concentrations in 47 subjects four times and urinary cadmium concentrations in 48 subjects twice, during a 3-year period.
Between-person and within-person variance components of these variables were estimated using a random-effects one-way analysis of variance model.
The intraclass correlation coefficient (ICC) for urinary bêta2-microglobulin concentration, when expressed as mug/g creatinine and mug/l, was 0.92 and 0.89, respectively.
The ICC for standardized urinary cadmium concentration (expressed as mug/g creatinine) was 0.81, while it decreased to 0.33 without standardization.
The findings suggest that single measurement of urinary bêta2-microglobulin and cadmium, when expressed as a function of creatinine, can reliably estimate average levels over at least a 3-year period.
Standardization of concentration using urinary creatinine improved reproducibility especially for urinary cadmium excretion.
Mots-clés Pascal : Méthode étude, Reproductibilité, Epidémiologie, Analyse statistique, Analyse corrélation, Japon, Asie, Pollution sol, Cadmium, Métal lourd, Analyse chimique, Microglobuline bêta2, Liquide biologique, Urine, Homme
Mots-clés Pascal anglais : Investigation method, Reproducibility, Epidemiology, Statistical analysis, Correlation analysis, Japan, Asia, Soil pollution, Cadmium, Heavy metal, Chemical analysis, bêta2-Microglobulin, Biological fluid, Urine, Human
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0315563
Code Inist : 002B03L05. Création : 12/09/1997.