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  1. Ochratoxin A in human sera in the area with endemic nephropathy in Croatia.

    Article - En anglais

    Ochratoxin A (OA) is nephrotoxic fungal metabolite (mycotoxin) occurring in foodstuffs.

    The compound is causally associated with mycotoxin porcine nephropathy, a disease comparable with a human kidney disease called endemic nephropathy (EN).

    In this paper we presented results obtained over a 10-year period in the hyperendemic village Kaniza, and in control villages where no clinical cases of nephropathy had been found.

    In the hyperendemic village Kaniza and non-endemic villages the incidence of OA in human blood was up to 4.5% (range 2-50 mg/ml) and up to 2.4% (range 2-10 ng/ml), respectively.

    Almost all samples of food and feed, collected randomly in the hyperendemic village were found to contain OA.

    Considering marked exposure to OA in Kaniza, it was assumed that incidence of EN in this population could be related to OA contamination of food and feed.

    Mots-clés Pascal : Toxicité, Mycotoxine, Produit alimentaire, Ochratoxine, Rein, Homme, Epidémiologie, Croatie, Europe, Analyse chimique, Liquide biologique, Sang, Sérum, Néphropathie endémique, Fièvre hémorragique, Arbovirose, Virose, Infection, Appareil urinaire pathologie, Ochratoxine A, Kaniza

    Mots-clés Pascal anglais : Toxicity, Mycotoxin, Foodstuff, Ochratoxin, Kidney, Human, Epidemiology, Croatia, Europe, Chemical analysis, Biological fluid, Blood, Serum, Endemic nephropathy, Hemorrhagic fever, Arbovirus disease, Viral disease, Infection, Urinary system disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0315558

    Code Inist : 002A05D05. Création : 12/09/1997.