The field of molecular epidemiology, using modern epidemiological approaches and taking the advantage of the advances in molecular biology can provide new tools for the exploration of etiological determinants, either environmental or hereditary, in the development of hematological neoplasms.
It is now possible to identify some host susceptibility characteristics, to measure the effective dose of exposure, and to identify early, pre-clinical biological effects, using sensitive and specific biomarkers.
The significant variation in the incidence of hematological neoplasms in different geographical areas, races, and age groups, the high rates of familial aggregation in certain populations, the involvement of protooncogenes and tumor suppressor genes in the development of hematological neoplasms, as well as of many environmental agents such as chemicals, radiation, and viruses, support the important role of molecular epidemiology in the investigation of the development of hematological neoplasms.
Mots-clés Pascal : Hémopathie maligne, Epidémiologie moléculaire, Déterminisme génétique, Prédisposition, Génétique, Environnement, Homme
Mots-clés Pascal anglais : Malignant hemopathy, Molecular epidemiology, Genetic inheritance, Predisposition, Genetics, Environment, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0315538
Code Inist : 002B19B. Création : 12/09/1997.