To report the prevalence of age-related maculopathy (ARM) in Salandra, a small, isolated southern Italian community, to test the hypothesis that an environmental factor, scarce in such a remote community but ubiquitous in modern industrial societies, might modify the risk of developing ARM.
Population-based cross-sectional survey.
Prevalence of advanced age-related macular degeneration (ARMD) (geographic atrophy or exudative maculopathy) and ARM (large, soft drusen or retinal pigment epithelium changes, or both) defined by fundus biomicroscopy and 30° stereoscopic macular photography.
Self-sustenance was assessed by interview of participants and local shop retailers.
The degree of genetic isolation was computed using a model that fits the genetic population structure with the frequency distribution of surnames in the community.
A full ophthalmic examination was undertaken in 366 (63.5%) of 576 eligible participants, 354 (96.7%) of whom had clinical or photographic assessment for the presence of ARMD and 310 (84.6%) of whom had drusen characteristics graded on color transparencies for ARM.
The overall prevalence of ARMD was 1.1%. Drusen larger than 50 mum and more numerous than 10 were found in 4.5% of subjects.
Salandra was the birthplace of 87.2% of participants and for 77.3% of both parents of each subject.
People in the community tended to consume homegrown products. (...)
Mots-clés Pascal : Dégénérescence, Macula, Age, Italie, Europe, Sud, Zone rurale, Prévalence, Epidémiologie, Homme, Oeil pathologie, Rétinopathie, Maculopathie
Mots-clés Pascal anglais : Degeneration, Macula, Age, Italy, Europe, South, Rural area, Prevalence, Epidemiology, Human, Eye disease, Retinopathy, Maculopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0315169
Code Inist : 002B09I. Création : 12/09/1997.