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  1. Age-related macular disease in rural southern Italy.

    Article - En anglais


    To report the prevalence of age-related maculopathy (ARM) in Salandra, a small, isolated southern Italian community, to test the hypothesis that an environmental factor, scarce in such a remote community but ubiquitous in modern industrial societies, might modify the risk of developing ARM.


    Population-based cross-sectional survey.

    Main Outcome Measures 

    Prevalence of advanced age-related macular degeneration (ARMD) (geographic atrophy or exudative maculopathy) and ARM (large, soft drusen or retinal pigment epithelium changes, or both) defined by fundus biomicroscopy and 30° stereoscopic macular photography.

    Self-sustenance was assessed by interview of participants and local shop retailers.

    The degree of genetic isolation was computed using a model that fits the genetic population structure with the frequency distribution of surnames in the community.


    A full ophthalmic examination was undertaken in 366 (63.5%) of 576 eligible participants, 354 (96.7%) of whom had clinical or photographic assessment for the presence of ARMD and 310 (84.6%) of whom had drusen characteristics graded on color transparencies for ARM.

    The overall prevalence of ARMD was 1.1%. Drusen larger than 50 mum and more numerous than 10 were found in 4.5% of subjects.

    Salandra was the birthplace of 87.2% of participants and for 77.3% of both parents of each subject.

    People in the community tended to consume homegrown products. (...)

    Mots-clés Pascal : Dégénérescence, Macula, Age, Italie, Europe, Sud, Zone rurale, Prévalence, Epidémiologie, Homme, Oeil pathologie, Rétinopathie, Maculopathie

    Mots-clés Pascal anglais : Degeneration, Macula, Age, Italy, Europe, South, Rural area, Prevalence, Epidemiology, Human, Eye disease, Retinopathy, Maculopathy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0315169

    Code Inist : 002B09I. Création : 12/09/1997.