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  1. Quantitative estimates of the impact of sensitivity and specificity in mammographic screening in Germany.

    Article - En anglais

    Study objective

    To estimate quantitatively the impact of the quality of mammographic screening (in terms of sensitivity and specificity) on the effects and costs of nationwide breast cancer screening.


    Three plausible « quality » scenarios for a biennial breast cancer screening programme for women aged 50-69 in Germany were analysed in terms of costs and effects using the Microsimulation Screening Analysis model on breast cancer screening and the natural history of breast cancer.

    Firstly, sensitivity and specificity in the expected situation (or « baseline » scenario) were estimated from a model based analysis of empirical data from 35 000 screening examinations in two German pilot projects.

    In the second « high quality » scenario, these properties were based on the more favourable diagnostic results from breast cancer screening projects and the nationwide programme in The Netherlands.

    Thirdly, a worst case, « low quality » hypothetical scenario with a 25% lower sensitivity than that experienced in The Netherlands was analysed.


    The epidemiological and social situation in Germany in relation to mass screening for breast cancer.


    In the « baseline » scenario, an 11% reduction in breast cancer mortality was expected in the total German female population, ie 2100 breast cancer deaths would be prevented per year. (...)

    Mots-clés Pascal : Mammographie, Dépistage, Tumeur maligne, Glande mammaire, Assurance qualité, Evaluation, Programme sanitaire, Prévention, Analyse coût efficacité, Femme, Homme, Allemagne, Europe, Simulation ordinateur, Radiodiagnostic, Glande mammaire pathologie

    Mots-clés Pascal anglais : Mammography, Medical screening, Malignant tumor, Mammary gland, Quality assurance, Evaluation, Sanitary program, Prevention, Cost efficiency analysis, Woman, Human, Germany, Europe, Computer simulation, Radiodiagnosis, Mammary gland diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0312515

    Code Inist : 002B30A01C. Création : 12/09/1997.