Feasibility study for use of brush cytology as a complementary method for diagnosis of rectal cancer.
Meeting of The American Society of the Colon and Rectal Surgeons. Seattle, Washington (USA), 1996/06/09.
Brush cytology has previously been described as a feasible method for accurately diagnosing colorectal cancer.
This study was designed : 1) to determine the sensitivity and specificity of brush cytology for the diagnosis of rectal cancer ; 2) to prospectively assess the extent of interobserver variability with this technique ; 3) to prospectively examine the cost impact of the addition of brush cytology as a routine method of confirming the diagnosis of rectal cancer.
PATIENTS AND METHODS
Three hundred fifty-seven patients who attended a rectal clinic and who were found to have a lesion between January 1990 and March 1996 were assessed.
Each patient underwent rigid proctoscopy, followed by brush cytology and tissue biopsy.
Results were compared with the final histologic diagnosis in each patient.
The brushings from the last 92 consecutive patients in this series were independently examined by four cytologists and a pathologist to determine the rate of interobserver variability.
Rectal adenocarcinoma was confirmed from surgically resected specimens in 303 patients.
Brush cytology accurately diagnosed 278 of them.
Of the remaining 25 patients, two had brushings that were insufficient for diagnosis.
There was one false-positive case.
Forceps biopsy correctly identified cancer in 260 patients, with no false-positive interpretations. (...)
Mots-clés Pascal : Carcinome, Rectum, Diagnostic, Exploration cytologique, Brossage, Sensibilité, Spécificité, Comparaison interindividuelle, Coût, Evaluation performance, Homme, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Rectum pathologie, Anatomopathologie, Economie santé
Mots-clés Pascal anglais : Carcinoma, Rectum, Diagnosis, Cytologic investigation, Brushing, Sensitivity, Specificity, Interindividual comparison, Costs, Performance evaluation, Human, Malignant tumor, Digestive diseases, Intestinal disease, Rectal disease, Pathology, Health economy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0311184
Code Inist : 002B24O06. Création : 15/07/1997.