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  1. Increased prevalence of Helicobacter pylori infection among patients affected with intestinal-type gastric cancer at non-cardiac locations.

    Article - En anglais

    Previous data on the association of Helicobacter pylori infection with gastric cancer by demographic or histological features are inconsistent due to a univariate analysis of limited case numbers.

    The aim of the present study was to determine such an association by the use of a large series of patients and multiple variables analysis.

    The serum IgG antibodies against H. pylori were measured in 397 patients with histologically verified gastric cancer.

    A multiple logistic regression analysis was used to define the association between seropositivity and demographic or tumour characteristics of gastric cancer.

    The overall seropositivity of H. pylori was 63%. In univariate analysis, the prevalence was significantly lower among patients with cardia (50%) or diffuse-type (56.6%) cancers than those with non-cardia (64.8%) or intestinal-type (70.3%) cancer (P<0.05 and P<0.01, respectively).

    There was no statistical difference between H. pylori infection rate and gender, age or tumour stage.

    A multiple logistic regression analysis showed tumour location and histology remained significant factors associated with seropositivity of H. pylori with an odds ratio of approximately 2.0. Analysis of combined histology and location revealed that patients with intestinal-type cancer at non-cardia locations had the highest odds ratio of 3.93 (95% confidence interval (CI) : 1.55-10.0) compared with the lowest odds ratio of 0.69 (95% CI : 0.30-1.62) in diffuse cardia cancer (P<0.005). (...)

    Mots-clés Pascal : Carcinome, Estomac, Incidence, Gastrite, Campylobactériose, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Association morbide, Facteur risque, Mesure, Séropositivité, Localisation, Grade histologique, Epidémiologie, Homme, Tumeur maligne, Appareil digestif pathologie, Estomac pathologie

    Mots-clés Pascal anglais : Carcinoma, Stomach, Incidence, Gastritis, Campylobacter infection, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Concomitant disease, Risk factor, Measurement, Seropositivity, Localization, Histological grading, Epidemiology, Human, Malignant tumor, Digestive diseases, Gastric disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0311135

    Code Inist : 002B05B02F. Création : 15/07/1997.