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  1. Occupational asthma caused by triglycidyl isocyanurate (TGIC).

    Article - En anglais

    Background Polyester powder paints are extensively used in metal painting.

    Triglycidyl isocyanurate (TGIC), an epoxy compound, is often used as a hardener.

    Several cases of allergic eczema from occupational exposure to TGIC have been reported in the literature.

    Objective We examined a 36-year-old non-smoking man who worked mainly as a spray painter, using a polyester powder paint containing 4% TGIC.

    During painting he used protective clothing and a motorized breathing protector.

    After 4 years he developed eczema on his hands, face and body, and an occupational allergic eczema caused by TGIC was diagnosed.

    He also suffered from powder-paint-related asthmatic symptoms.

    Methods Occupational asthma was diagnosed in accordance with the accepted guidelines.

    Inhalation challenge tests were performed with the paint and TGIC.

    Results Spirometry showed slight obstruction ; the blood eosinophils and serum IgE value were elevated.

    Skin-prick tests with common environmental allergens were negative.

    The challenge test with lactose powder was also negative.

    A challenge test with a paint containing TGIC (4%) induced a dual reaction in PEF and a late 23% fall in FEV1.

    A test with TGIC (4%) mixed with lactose induced a dual PEF reaction, and also dual changes in spirometry.

    The PD15 in the histamine challenge test decreased significantly after the challenge tests.

    Conclusions To our knowledge this is the first diagnosed case of occupational asthma caused by TGIC. (...)

    Mots-clés Pascal : Asthme, Dermatite contact, Allergie, Isocyanate polymère, Peinture poudre, Ester polymère, Epoxyde résine, Exposition professionnelle, Composé chimique, Toxicité, Etude cas, Adulte, Homme, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Peau pathologie, Immunopathologie, Maladie professionnelle, Médecine travail

    Mots-clés Pascal anglais : Asthma, Contact dermatitis, Allergy, Isocyanate polymer, Powder paint, Ester polymer, Epoxy resin, Occupational exposure, Chemical compound, Toxicity, Case study, Adult, Human, Respiratory disease, Obstructive pulmonary disease, Skin disease, Immunopathology, Occupational disease, Occupational medicine

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0311129

    Code Inist : 002B06C02. Création : 15/07/1997.