Community respiratory virus infections in immunocompromised patients with cancer.
Symposium "Community Respiratory Viral Infections in the Immunocompromised Host". .
Community respiratory viruses, such as respiratory syncytial virus (RSV), influenza viruses, parainfluenza viruses, adenoviruses, and picornaviruses, are an important cause of respiratory disease in the immunocompromised adult with cancer.
Recent studies have demonstrated that a minimum of 31% of adult bone marrow transplant (BMT) recipients and 18% of adults with leukemia who are hospitalized with an acute respiratory illness have a community respiratory virus infection.
The temporal occurrence of these infections in immunocompromised patients tends to mirror their occurrence in the community.
The clinical illnesses range from self-limited upper respiratory illnesses to fatal pneumonias, depending on the type of virus and the type and degree of immunosuppression.
The pneumonias may be viral, bacterial/fungal, or mixed.
The highest frequency of progression to fatal viral pneumonia has been reported for RSV infections in recently transplanted BMT recipients and myelosuppressed patients with leukemia.
Studies have suggested that early therapy for RSV pneumonia with a combination of aerosolized ribavirin and intravenous immunoglobulin may be of benefit.
Defining effective prophylactic and therapeutic strategies will be a challenge, given the diversity of viruses, the wide spectrum of immunocompromised patients with varying vulnerability to serious community respiratory virus disease, and the frequent presence of other opportunistic infections and medical problems. (...)
Mots-clés Pascal : Infection, Appareil respiratoire, Virose, Immunodéficit, Tumeur maligne, Facteur risque, Infection communautaire, Epidémiologie, Traitement, Virus syncytial humain, Spumavirinae, Retroviridae, Virus, Antiviral, Chimiothérapie, Immunoprophylaxie, Homme, Appareil respiratoire pathologie, Immunopathologie, Organisation santé
Mots-clés Pascal anglais : Infection, Respiratory system, Viral disease, Immune deficiency, Malignant tumor, Risk factor, Community acquired infection, Epidemiology, Treatment, Human syncytial virus, Spumavirinae, Retroviridae, Virus, Antiviral, Chemotherapy, Immunoprophylaxis, Human, Respiratory disease, Immunopathology, Public health organization
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0310710
Code Inist : 002B05C02C. Création : 15/07/1997.