Objectives-To calculate age adjusted risks for multiple sclerosis in relatives of Flemish patients with multiple sclerosis.
Methods-Lifetime risks were calculated using the maximum likelihood approach.
Vital information was obtained on 674 probands with multiple sclerosis in Flanders and a total of their 26 225 first, second, and third degree relatives.
Full medical information to allow documentation of multiple sclerosis status was available for 21 351 (81.4%) relatives.
The age adjusted risk for parents was 1.61 (SEM 0.35)%, for siblings 2.10 (SE 0.36)%, and for children 1.71 (SEM 0.70)%. For aunts and uncles, the risk was 0.66 (SEM 0.13)%. Conclusion-The risk for first degree relatives of patients with multiple sclerosis in Flanders is increased 10-fold to 12-fold ; for second degree relatives, it is increased threefold.
This information can be used for risk counselling in families and provides additional support for the role of more than one locus contributing to the susceptibility of multiple sclerosis.
Mots-clés Pascal : Sclérose en plaque, Belgique, Europe, Risque naturel, Etude familiale, Epidémiologie, Taux risque, Homme, Système nerveux pathologie, Système nerveux central pathologie, Maladie inflammatoire, Flandres, Maladie familiale
Mots-clés Pascal anglais : Multiple sclerosis, Belgium, Europe, Natural hazard, Family study, Epidemiology, Risk rate, Human, Nervous system diseases, Central nervous system disease, Inflammatory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0309907
Code Inist : 002B17F. Création : 15/07/1997.