This study developed a new acquired immunodeficiency syndrome (AIDS) severity system by including diagnostic, physiological, functional, and socio-demographic factors predictive of survival.
Three-hundred five persons with AIDS in Boston were interviewed ; their medical records were reviewed and vital status ascertained.
Overall median (±SD) survival for the cohort from the first interview until death was 560 ± 14.4 days.
The best model for predicting survival, the Boston AIDS Survival Score, included the Justice score (stage 2 relative hazard [RH]=1.25,95% confidence interval [Cl]=0.80,1.96 ; stage 3 RH=1.76,95% Cl=1.15,2.70), a newly developed opportunistic disease score (Boston Opportunistic Disease Survival Score ; stage 2 RH=1.35,95% CI=0.90,2.02 ; stage 3 RH=2.10,95% Cl=1.38,3.18), and measures of activities of daily living (any intermediate limitations, RH=1.84,95% Cl=1.05,3.21 ; any basic limitations, RH=2.60,95% Cl=1.44,4.69).
This model had substantially greater predictive power (R2=17, C statistic=68) than the Justice score alone (R2=09, C statistic=61).
Incorporating data on clinically important events and functional status into a physiologically based system can improve the prediction of survival with AIDS.
Mots-clés Pascal : Echelle évaluation, Psychométrie, Indice gravité, Survie, Homme, SIDA, Virose, Infection, Facteur prédictif, Capacité fonctionnelle, Diagnostic, Immunopathologie, Immunodéficit, Facteur sociodémographique, Boston AIDS Survival Score
Mots-clés Pascal anglais : Evaluation scale, Psychometrics, Severity score, Survival, Human, AIDS, Viral disease, Infection, Predictive factor, Functional capacity, Diagnosis, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0307346
Code Inist : 002B30A01A1. Création : 15/07/1997.