Biological monitoring of exposure to chlorpyrifos-methyl by assay of urinary alkylphosphates and 3,5,6-trichloro-2-pyridinol.
The results of biological monitoring by assay of urinary 3,5,6-trichloro-2. pyridinol and alkylphosphates (DMP, DMTP) in groups of 9 and 2 workers exposed to chlorpyrifos-methyl during vine spraying and manual leaf thinning 5-11 d after spraying, respectively, are reported.
The results are compared with those of a control group of 46 subjects not occupationally exposed to organophosphate insecticides.
Significantly higher urinary excretion of metabolites (Mann-Whitney U-test) was found in both groups than in controls.
Levels of 3,5,6-trichloro-2-pyridinol (mean ± SD) were 15.9+10.6 nmol/g creatinine (n=33) for controls, 92.4+162.5 nmol/g creatinine (n=20) for manual workers, and 675.5+1110.8 nmol/g creatinine (n=48) for workers spraying and mixing the insecticide.
Levels of DMP (mean ± SD) were 63.8+100. 1 nmol/g creatinine (n=42), 123.0+79.0 nmol/g creatinine (n=20), and 577.2+1003.2 nmol/g creatinine (n=61), respectively, for the same 3 groups.
Levels of DMTP (mean ± SD) were 153.4+164.4 nmol/g creatinine (n=43), 489.3+288.3 nmol/g creatinine (n=20), and 297.6+215.4 nmol/g creatinine (n=61), respectively, for the same 3 groups.
Good correlations were found between urinary excretion of 3,5,6-trichloro-2-pyridinol and DMP (r=776 for manual workers ; r=775 for workers mixing and spraying the insecticide) or DMTP (r=558 and r=746, respectively for the same 2 groups). (...)
Mots-clés Pascal : Surveillance biologique, Liquide biologique, Urine, Homme, Exposition professionnelle, Industrie agricole, Insecticide, Organophosphoré, Pesticide, Métabolite, Médecine travail, Epidémiologie, Toxicocinétique, Cinétique, Excrétion, Activité enzymatique, Cholinesterase, Carboxylic ester hydrolases, Esterases, Hydrolases, Enzyme, Chlorpyrifos-méthyl, Phosphate(alkyl), Pyridin-2-ol(3,5,6-trichloro)
Mots-clés Pascal anglais : Biological monitoring, Biological fluid, Urine, Human, Occupational exposure, Agricultural industry, Insecticide, Organophosphorus compounds, Pesticides, Metabolite, Occupational medicine, Epidemiology, Toxicokinetics, Kinetics, Excretion, Enzymatic activity, Cholinesterase, Carboxylic ester hydrolases, Esterases, Hydrolases, Enzyme
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0305046
Code Inist : 002B03G. Création : 15/07/1997.