Silicas and silicates are some of the most abundant compounds found naturally in the earth's crust.
Excessive exposure to crystalline silicas can cause serious lung disease such as silicosis and has been associated with lung cancer in some studies, but the potential health effects of amorphous silicas (silicon dioxide without crystalline structure) have not been well studied.
Results from animal studies of amorphous silicas, unlike those seen with crystalline silicas, have suggested limited and largely reversible cytotoxic and possibly fibrogenic effects associated with some forms, but data on cancer outcomes are scanty and for the most part negative.
Epidemiologic investigations to date for any potential cancer risk are not informative because the effects of crystalline and amorphous silicas have not been separated.
Any future epidemiologic study should attempt to clarify the health effects of amorphous silicas from those of crystalline silicas, particularly with regard to any potential for carcinogenicity.
Mots-clés Pascal : Article synthèse, Toxicité, Carcinogène, Composé chimique, Silicium Composé, Silice, Matériau amorphe, Inhalation, Homme, Maladie professionnelle, Exposition professionnelle, Médecine travail, Etats Unis, Amérique du Nord, Amérique, Europe, Epidémiologie, Tumeur maligne, Pneumoconiose, Silicose, Appareil respiratoire pathologie, Poumon pathologie
Mots-clés Pascal anglais : Review, Toxicity, Carcinogen, Chemical compound, Silicon Compounds, Silica, Amorphous material, Inhalation, Human, Occupational disease, Occupational exposure, Occupational medicine, United States, North America, America, Europe, Epidemiology, Malignant tumor, Pneumoconiosis, Silicosis, Respiratory disease, Lung disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0304106
Code Inist : 002B04E02. Création : 15/07/1997.