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  1. Influence of other maternal variables on the relationship between maternal virus load and mother-to-infant transmission of human immunodeficiency virus type 1.

    Article - En anglais

    To assess the relationship between maternal human immunodeficiency virus (HIV) type 1 RNA level, other important covariates, and mother-to-infant (vertical) transmission of HIV-1, third trimester repository specimens from 160 HIV-1-seropositive women enrolled in the Mothers and Infants Cohort Study between 1986 and 1991 were assayed in batch for HIV-1 RNA.

    A significant association between peripheral blood HIV-1 RNA level and vertical transmission remained after controlling for CD4 cell level, duration of ruptured membranes, « hard » drug (cocaine and heroin) use, and frequency of sexual activity during pregnancy.

    However, the association was attenuated among women with advanced HIV infection and those with a high frequency of sexual activity during pregnancy.

    In these settings, interventions that target risk factors other than virus load may be particularly important for preventing vertical transmission of HIV-1.

    Mots-clés Pascal : Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Transmission mère enfant, Epidémiologie, Facteur risque, Relation sexuelle, Stade clinique, Homme, Femelle, SIDA, Virose, Infection, Immunopathologie, Immunodéficit

    Mots-clés Pascal anglais : HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Mother to child transmission, Epidemiology, Risk factor, Sexual intercourse, Clinical stage, Human, Female, AIDS, Viral disease, Infection, Immunopathology, Immune deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0303928

    Code Inist : 002B06D01. Création : 15/07/1997.