Influence of other maternal variables on the relationship between maternal virus load and mother-to-infant transmission of human immunodeficiency virus type 1.
To assess the relationship between maternal human immunodeficiency virus (HIV) type 1 RNA level, other important covariates, and mother-to-infant (vertical) transmission of HIV-1, third trimester repository specimens from 160 HIV-1-seropositive women enrolled in the Mothers and Infants Cohort Study between 1986 and 1991 were assayed in batch for HIV-1 RNA.
A significant association between peripheral blood HIV-1 RNA level and vertical transmission remained after controlling for CD4 cell level, duration of ruptured membranes, « hard » drug (cocaine and heroin) use, and frequency of sexual activity during pregnancy.
However, the association was attenuated among women with advanced HIV infection and those with a high frequency of sexual activity during pregnancy.
In these settings, interventions that target risk factors other than virus load may be particularly important for preventing vertical transmission of HIV-1.
Mots-clés Pascal : Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Transmission mère enfant, Epidémiologie, Facteur risque, Relation sexuelle, Stade clinique, Homme, Femelle, SIDA, Virose, Infection, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Mother to child transmission, Epidemiology, Risk factor, Sexual intercourse, Clinical stage, Human, Female, AIDS, Viral disease, Infection, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0303928
Code Inist : 002B06D01. Création : 15/07/1997.