Prospective follow-up study of 877 children born after intracytoplasmic sperm injection (ICSI), with ejaculated epididymal and testicular spermatozoa and after replacement of cryopreserved embryos obtained after ICSI. Discussion.
International Symposium on Genetics and Outcomes of Assisted Reproductive Technology. Brussels (BEL), 1995/12/09.
A prospective follow-up study of 877 children born after ICSI was carried out.
The aim of this study was to compile data on karyotypes, congenital malformations, growth parameters and developmental milestones so as to evaluate the safety of this new technique.
The follow-up study included agreement to genetic counselling and prenatal diagnosis and was based on a physical examination at the Centre for Medical Genetics (Dutch-speaking Brussels Free University, Brussels, Belgium) at 2 months, 1 year and 2 years, when major and minor malformations and a psychomotor evolution were recorded.
Between April 1991 and July 1995,904 pregnancies obtained after intracytoplasmic sperm injection (ICSI) led to the birth of 877 children (465 singletons, 379 twins and 33 triplets).
Prenatal diagnosis determined a total of 486 karyotypes, of which six were abnormal (1.2%) and six (1.2%) were familial structural aberrations, all transmitted from the father.
This slight increase in de-novo chromosomal aberrations and the higher frequency of transmitted chromosomal aberrations are probably linked directly to the characteristics of the infertile men treated rather than to the ICSI procedure itself.
In all, 23 (2.6%) major malformations were observed in the children born, defined as those causing functional impairment or requiring surgical correction.
No particular malformation was disproportionately frequent. (...)
Mots-clés Pascal : Injection spermatozoïde intracytoplasmique, Pronostic, Malformation, Congénital, Caryotype, Etude longitudinale, Epidémiologie, Facteur risque, Procréation assistée, Homme, Mâle
Mots-clés Pascal anglais : Intracytoplasmic sperm injection, Prognosis, Malformation, Congenital, Karyotype, Follow up study, Epidemiology, Risk factor, Assisted procreation, Human, Male
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Cote : 97-0303315
Code Inist : 002B20A04. Création : 15/07/1997.