International Symposium on Genetics and Outcomes of Assisted Reproductive Technology. Brussels (BEL), 1995/12/09.
Various methodological pitfalls preclude simple validation of the ostensible safety of offspring conceived thorough assisted reproductive technologies (ART).
These pitfalls include lack of an appropriate comparison group (control), failure to take into account potential confounding variables, anomaly surveillance that is either too rigorous or too lax compared to the way in which anomalies are sought in general population surveys, and inconsistent criteria with respect to classifying anomalies (inclusion or exclusion of minor anomalies, internal anomalies evident only on ultrasound, and anomalies present in terminated pregnancies).
To minimise these pitfalls, we recommend prospective surveillance for major anomalies, best defined as defects resulting in death, causing major handicap or necessitating surgery.
Surveillance should ideally begin as soon as pregnancy is diagnosed.
Data should be gathered allowing potential confounding variables to be taken into account, and systematic neonatal surveillance for anomalies should be performed during a designated time interval.
Mots-clés Pascal : Procréation assistée, Maladie congénitale, Facteur risque, Epidémiologie, Homme
Mots-clés Pascal anglais : Assisted procreation, Congenital disease, Risk factor, Epidemiology, Human
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0302253
Code Inist : 002B20A04. Création : 15/07/1997.