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  1. Community-based study of Lennox-Gastaut syndrome.

    Article - En anglais

    Purpose 

    Before 1986, the spectrum of childhood epilepsies, including Lennox-Gastaut syndrome (LGS) and Doose syndrome (DS), known collectively as « epilepsia myoclonica astatica, » was believed to represent a single disease.

    More recently, some investigators have considered these syndromes to be parts of a continuum.

    To clarify these theories, neurobiologic factors of the syndromes were studied to determine which qualities were shared and which were unique.

    Methods 

    A retrospective (1975-1985), community-based (Helsinki metropolitan area and the province of Uu-simaa) study was designed to seek children with features of LGS and DS.

    It was assumed that recall bias and the selection of documented history would be similar throughout the group.

    Ranks of increasing pathology were assigned to different seizure types, EEG results, and drug treatments.

    A similar procedure was applied to epidemiologic data.

    Spearman rank-order correlations were calculated to determine which features correlated with LGS and which correlated with less severe epilepsy.

    Results 

    The survey comprised 75 patients with broadly defined LGS.

    The annual incidence was 2 in 100,000 children aged 0 to 14 years.

    Prenatal or perinatal abnormalities did not correlate with severity of epilepsy. (...)

    Mots-clés Pascal : Epilepsie Lennox, Myoclonie, Incidence, Finlande, Europe, Gravité, Etude comparative, Classification, Epidémiologie, Enfant, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Trouble neurologique, Mouvement involontaire, Doose syndrome

    Mots-clés Pascal anglais : Lennox syndrome, Myoclonus, Incidence, Finland, Europe, Gravity, Comparative study, Classification, Epidemiology, Child, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder, Neurological disorder, Involuntary movement

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0299779

    Code Inist : 002B17A03. Création : 15/07/1997.