Association of seropositivity for hepatitis viruses and aplastic anemia in Thailand.
Aplastic anemia is more common in the Orient than in western countries, with an incidence in Thailand that is 2-to 3-fold higher than in Europe.
Aplastic anemia after hepatitis is a well characterized clinical entity, and clinical hepatitis is also prevalent in the Far East.
We performed a prospective case-control study to determine risk factors for aplastic anemia in Bangkok and two rural regions during 1989 to 1994.
A total of 375 cases were identified, along with 1,174 hospital controls matched for age and sex.
Historical data were collected by trained interviewers.
Sera from a subset of cases (N=177) and controls (N=183) were tested for antibodies to hepatitis viruses A, B, and C and hepatitis B surface antigen.
There was no evidence of association of aplastic anemia with hepatitis B or hepatitis C. Previous exposure to hepatitis A, as determined by immunoglobulin G (IgG) seropositivity, was significantly associated with aplastic anemia : the relative risk adjusted for confounding was 2.9 (95% confidence interval 1.2-6.7).
The same association also existed for persons under age 25 years, in whom the prevalence of hepatitis A IgG was lower than in the total population.
However, no patients showed evidence of recent infection with hepatitis A (immunoglobulin M [IgM] seropositivity). (...)
Mots-clés Pascal : Hépatite virale, Virose, Infection, Symptomatologie, Séropositivité, Anémie aplasique, Association morbide, Incidence, Epidémiologie, Homme, Thaïlande, Asie, Appareil digestif pathologie, Foie pathologie, Hémopathie
Mots-clés Pascal anglais : Viral hepatitis, Viral disease, Infection, Symptomatology, Seropositivity, Aplastic anemia, Concomitant disease, Incidence, Epidemiology, Human, Thailand, Asia, Digestive diseases, Hepatic disease, Hemopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0299735
Code Inist : 002B05C02G. Création : 15/07/1997.