Hepatitis B (HB) immunization was introduced as part of the expanded programme on immunization (EPI) in two provinces in Thailand and evaluated over a four year period.
Three doses of HB vaccine were offered to 60980 newborns at birth, 2 and 6 months of age.
The overall coverage for complete HB immunization was 90.4%. Serosurveys of randomly selected children under the age of 5 years were undertaken before and at the end of the project.
Levels of HBsAg positivity were reduced by 85%, and there was a corresponding 70% increase in protective immunity.
These findings demonstrate that HB immunization can be successfully integrated into EPI without adverse effect on coverage rates of other antigens, and results in a marked reduction in the rate of chronic carriage of HB virus in preschool age children.
Mots-clés Pascal : Nourrisson, Homme, Vaccination, Programme sanitaire, Hépatite virale B, Virose, Infection, Appareil digestif pathologie, Foie pathologie, Thaïlande, Asie, Zone tropicale
Mots-clés Pascal anglais : Infant, Human, Vaccination, Sanitary program, Viral hepatitis B, Viral disease, Infection, Digestive diseases, Hepatic disease, Thailand, Asia, Tropical zone
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0298075
Code Inist : 002B05A02. Création : 15/07/1997.