High-dose exposure to inorganic mercury in man can influence the immune system and in rare cases cause immune-related disease.
Some experimental animals also react with autoimmunity after low doses of inorganic mercury.
Glomerulonephritis and an increased formation of immunoglobulin type E (IgE) are characteristic of these reactions.
A recent study of 15-year-old adolescents demonstrated an association between immunoglobulin type A (IgA) and mercury concentration in plasma (P-Hg).
There was also an association between allergic disease and IgA levels.
The present study included 54 male and 23 female 19-year-old students who were recruited from a cohort that had been previously defined in a survey of allergic disease.
Of the students, 39 (51%) had asthma, allergic rhino-conjunctivitis or eczema.
Similar amalgam burden and P-Hg levels were observed in students with n=39) and without (n=38) allergic disease (P=0.48 and P=0.98, respectively).
As expected, IgE levels were significantly higher in the group with allergic disease (P 0,006), but there was no association between P-Hg and IgE.
The P-Hg levels were very low (median 1.50 nmol/l) and correlated significantly (r=0.31) with the small number of amalgam surfaces (P=0.007).
Thirty-seven students had no amalgam fillings.
P-Hg levels did not associate significantly with IgA, but did so with IgG2 (r=0.33 ; P=0.003).
No conclusive correlation was observed between IgG2 and amalgam fillings. (...)
Mots-clés Pascal : Mercure, Métal lourd, Toxicité, Immunopathologie, Amalgame, Dent, Allergie, Système immunitaire, Immunoglobuline, IgE, IgA, Autoimmunité, Adolescent, Homme, Epidémiologie, Suède, Europe
Mots-clés Pascal anglais : Mercury, Heavy metal, Toxicity, Immunopathology, Amalgams, Tooth, Allergy, Immune system, Immunoglobulins, IgE, IgA, Autoimmunity, Adolescent, Human, Epidemiology, Sweden, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0297334
Code Inist : 002B03L05. Création : 15/07/1997.